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Miami Dolphins running back Ronnie Brown has been ruled out of Friday's game at the Carolina Panthers because of a foot injury, the team said on Wednesday.
Brown, 27, suffered the injury in Sunday's 25-23 win over Tampa Bay Buccaneers and the team said his prognosis was uncertain for the rest of the regular season.
Brown leads Miami in rushing for a fifth consecutive season, having rushed for 648 yards in this campaign.
He will be replaced on Friday by Ricky Williams.